Cold has killed living things since long before humans had fire. But what pulls the trigger inside the cell stayed murky. A Japanese team studying nematodes points to an unlikely suspect: copper.
A Japanese research team led by Gakushuin University has discovered Mitorubin, a plant-derived compound that simultaneously increases mitochondrial quantity and function. The compound improved heart function in aged mice and extended median lifespan by about 40% in obese mice on a high-fat diet — a distinct approach from US longevity biotech, NAD supplements, and senolytics.