Astellas and Kyowa Kirin are the first Japanese drugmakers to sign most-favored-nation pricing deals with Washington. A September 29 tariff deadline explains the timing, and Japanese prices sit inside the U.S. formula.
Japan recorded 86,473 IVF births in 2024, about 1 in 8 of its 686,173 births. Treatments fell to 550,265 while the multiple-birth rate rose to 4.15 percent, and the 2022 insurance reform helps explain both.
Japan has begun selling Telomelysin, a rewired cold virus that multiplies only inside cancer cells and goes into esophageal tumors by endoscope. Three doses list at 9.3 million yen; the trial behind it had 37 patients.
Tourists are buying eyeglasses in Japan, where no prescription is required and an Osaka store says it can go from eye test to handover in 25 minutes. In the US, a replacement pair can take two weeks to a month.
Cold sleep was a movie prop. Then ESA calculated that a hibernating crew would cut a Mars spacecraft's mass by a third, and a Japanese lab found the brain switch. With humans, it is still a matter of hours.
Seven Japanese research groups repeated two landmark University of Tokyo senolytics experiments under blinded conditions and found no effect. The original team's rebuttal ran the same day, in the same journal.
Mice spent two days in artificial hibernation and lost more than half the synapses in the hippocampus, yet still knew where the food was. What survived was not the big connections but the tightly clustered ones.
Kagawa University Hospital treated a three-year-old girl's recurrent C. diff colitis with her father's gut bacteria. A year on, no relapse. US-approved products exclude children, and the EU sets shared rules in 2027.
In 200 colorectal cancer patients from Tokyo and Osaka, 44.8 percent of tumours carried a gut bacterium's mutational signature, rising to about 70 percent under 40. The damage may predate the age of ten.
A German team had 50 students play Super Monkey Ball on a Wii and then work an arthroscopy box trainer. The game scores tracked surgical scores. Splatoon 2 did not, and gamer status predicted nothing.
PET scans of 37 patients whose hallucinations began after age 40 found tau, the protein behind Alzheimer's, in 64.9% of them against 14.9% of controls. They split into three near-equal groups.
Sensitive teeth affect roughly a third of adults in some surveys, and the usual fix is to seal the surface over. A Tokyo Dental College team has shown that 6-MSITC, a compound in Japanese wasabi, pushes dentin-building cells to lay down new tissue instead. It began with a question asked at a sushi counter in Kanda.
The first commercial transplant of AMCHEPRY, the world's first approved iPS cell-derived medicine, is set for October in Kyoto. Why proving it takes 35 patients and six years, and why the US and EU have no equivalent product.
A team at the Institute of Science Tokyo found resistance genes running harder inside hospital drain biofilm than in the wastewater itself. Why new pipes can backfire.
Tohoku University and Air Water went after the two bottlenecks that have kept photothermal cancer therapy in the lab for twenty years. IDP1, an artificial protein designed with AlphaFold, kept nanoparticles circulating for 150.5 minutes against 17.8 for PEG, and a 0.5 mm endoscope that fits inside a 16-gauge needle fired an 808 nm laser from inside the tumor at 28 percent less power. In mice, the tumors were gone within 14 days. How that compares with US trials already running in humans.
Rubbing a sore spot really does help. Kyushu University researchers have identified the touch neurons behind it in mice, a subpopulation called Npy2r-Cre that dampens pain signals in the spinal cord. The PNAS study puts specific cells behind the 1965 gate control theory.
Why does osteosarcoma cluster in the knees of growing teenagers? A University of Tokyo team, working from an accidental clue in aging research, has pieced together how the cancer starts: an accelerator gene (c-Myc), a brake gene (p53), and a signal from the bone's growth plate. It could reshape drug discovery for a rare cancer.
Researchers at Showa and Kansai Medical Universities grew mesothelial-like cells from human iPS cells to repair the peritoneum, the membrane that wears out and ends peritoneal dialysis. A look at the mouse proof-of-concept and why Japan's PD rate is so unusually low.
Japan's iPS cell therapy already treated fresh spinal injuries. Now a Keio University team is preparing a trial for the far harder chronic phase, where more than 100,000 patients have long been told regeneration simply isn't possible.
Toho University stroked infants on the head, back and belly. Only the back calmed them, at about 10.5 cm/s. In mouse pups raised without a mother, the response never appeared at all.