In 2025, a team of American mathematicians partially solved Hilbert's sixth problem, unresolved for 125 years. This groundbreaking achievement mathematically proves how microscopic particle motion gives rise to macroscopic fluid laws, shedding new light on the mystery of the "arrow of time."
Researchers at Japan's JAIST found that Ewingella americana, a bacterium from Japanese tree frog intestines, completely eliminated colorectal tumors in mice after a single dose, a 100% complete response rate that outperformed chemotherapy and immunotherapy in the same comparison. Here is what the preclinical study showed, and what it does not yet show.
Kagoshima University's oncolytic virus Surv.m-CRA-1 has entered a Phase 3 physician-led trial for primary malignant bone tumors, aiming at full approval. The therapy acts on cancer stem cells that conventional drugs struggle to reach, offering a possible new option for a cancer that has seen no new drug in over 30 years. Inside the mechanism, the Nippon Zoki licensing deal, the 2027 approval target, and what remains unproven.