Startups

Spider silk — five times stronger than steel by weight — is finally becoming a mass-produced reality. U.S.-based Kraig Biocraft targets 10 tons per month while Japan's Spiber partners with 45+ brands. Explore Super Silk's potential in fashion, medicine, and defense, and how this bio-revolution is unfolding.

Japanese startup Orizuru Therapeutics has begun clinical trials transplanting iPS cell-derived islet cells into diabetes patients. The first-ever transplant surgery succeeded in February 2025, with company-sponsored trials planned in Japan and the US. Over a decade after Professor Yamanaka's Nobel Prize, Japan's regenerative medicine enters the practical stage.

Japanese space startup Astroscale has announced its ISSA-J1 mission to realize a 'space safety patrol' service in orbit. As the space debris crisis intensifies with over 130 million pieces of junk circling Earth, this article explores how Astroscale's first-mover advantage in on-orbit servicing compares to rivals like ClearSpace and SpaceX, and what it means for Japan's growing space industry.

Japan's first two-story 3D-printed house "Stealth House" has been completed in Miyagi Prefecture, built by startups KIZUKI and ONOCOM with 20+ collaborating companies. As Japan's construction industry faces a severe labor shortage with 200,000+ fewer workers since 1997, multiple firms including Serendix and Lib Work are accelerating 3D concrete printing technology. We compare with U.S. giant ICON, explore Japan's strict building code compliance, and examine cost advantages.

Sakana AI, the Tokyo-based startup founded by former Google researchers, has raised $135M to reach a record $2.65B valuation — making it Japan's top unicorn. Citibank made its first-ever strategic investment in a Japanese company through this round. With backing from the CIA's venture arm and Google, Sakana is spearheading Japan's push for sovereign AI.

Visa, Qatar Investment Authority and Abu Dhabi Investment Authority are set to invest over up to $220 million as cornerstone investors in PayPay's Nasdaq IPO. With a valuation target of up to $14 billion, this could be the largest US listing by a Japanese company. A deep dive into PayPay's dual-mode QR/NFC strategy and its challenge to America's $2 trillion cash market.

Osaka University spinoff Reimei has launched the world's first corporate clinical trial of a corneal epithelial cell sheet made from donor-derived iPS cells. Learn how this breakthrough could solve the global corneal donor shortage, restore vision for millions, and where Japan's regenerative medicine regulation stands versus the US FDA.

A revolutionary pair of glasses born in Japan uses liquid lens technology to automatically adjust focus for myopia, farsightedness, and presbyopia. Developed by ViXion, a HOYA spinoff, the ViXion01S weighs just 33g and runs for 15 hours. With over $3.6 million raised in crowdfunding and a top government tech award, we explore this next-gen autofocus eyewear and the future of vision correction technology.

No batteries. Just 280 grams of rubber. A Japanese bone-setter turned entrepreneur created "futto," a walking support device using rubber tubes as artificial muscles. Built with hardware store materials by a 3-person family company, it's now scientifically validated and expanding overseas. Here's how this $220 innovation tackles aging societies worldwide.